Kate Jameson has outgrown her Brooklyn gang: Bina, Bunny, Barbie and Bev, aka the Bitches of Bushwick. While the Bs still go for French manicures and (gasp) matching furniture, Kate has embraced the urbane life. She has a Chelsea apartment and a neat job as school psychologist at Andrew Country Day "in the best neighborhood in Manhattan." But when Kate meets bad boy bar owner Billy Nolan in her natal borough, she instantly wants to get Brooklyn back into the girl. He's hot for her, too, but fate intervenes in the form of Kate's best friend, Elliot Winston. Elliot and his boyfriend, Brice, are determined to keep Kate from committing romantic folly yet again.